Ceramide mediates age-associated increase in macrophage cyclooxygenase-2 expression.
Authors Claycombe Kate J; Wu Dayong; Nikolova-Karakashian Mariana; Palmer Helen; Beharka Alison; Paulson K Eric; Meydani Simin Nikbin;
JournalJ Biol Chem
PubMed ID12072440
Previously, we showed that macrophages (MØ) from old mice have significantly higher levels of lipopolysaccharide (LPS)-induced prostaglandin E(2) (PGE(2)) production than young mice, due to increased cyclooxygenase-2 (COX-2) mRNA levels. The aim of the current study was to determine the underlying mechanisms of age-associated increase in COX-2 gene expression. The ... More